In Mecca, the news of their defeat preceded the subdued army, and proclaimed their resolve for vengeance. The aggressions of the Meccans reached their climax. The traders among them set aside a portion of their profits for the expenses of war. In 3/625, three thousand Meccan warriors, of whom 700 were clad in armour, bore down on Medina under the command of Abu Sufian. Their women accompanied them in front to applaud the brave and to chide the craven-hearted. Three miles to the north of Medina, the Meccans encamped at the foot of a hillock, called Uhud. It is a massive feature lying three miles north of Medina, and rising to the height of about 1000 feet above the level of the plain. The entire feature is 5 miles long. In the western part of Uhud, a large spur descends steeply to the ground, and to the right of this spur, as seen from the direction of Medina, a valley rises gently and goes up and away as it narrows, at a defile about 1000 yards from the foot of the spur. At the mouth of this valley, and at the foot of this spur, Muhammad took the position.
Against the enemy force of three thousand entrenched below Uhud, Muhammad mustered barely a thousand men. Of this number, three hundred were led by the traitor Abdullah bin Ubay, who marched with them only a little way and then deserted. This left only 700 men, of whom only 100 were mailed combatants. Muhammad went forth to command his force. To protect his rear against a surprise attack from the pass in the Uhud hills, he selected about fifty archers to cover this pass under the command of Abdullah bin Zubayr. According to Ibn Hisham (d. 218/833) in "Kitab Sirat-i Rasul Allah" (ed. F. Wustenfeld, Gottingen, 1860, 2nd vol., pp. 66-7), Muhammad told to the archers, "Use your arrows against the enemy cavalry. Keep the cavalry off our backs. As long as you hold your position, our rear is safe. On no account must you leave this position. If you see us winning, do not join us; if you see us losing, do not come to help us."
It was the morning of Saturday, 7th Shawal, 3/March 23, 625 - exactly a year and a week after the battle of Badr. The Meccans again made first inroad and once again the rout began a good number among them fled the field with the Muslims in hot pursuit. This would have been another consequent victory, but the Muslim archers posted on the adjoining mound, neglecting the injunctions of Muhammad, rashly left their places to join them in the pursuit of plunder, leaving a critical gap in Muhammad's defence. Muhammad had commanded them never to leave their position regardless of whether the Muslims plunged into the enemy camp and won, but the archers violated the orders in greed of spoils of war. The Meccan general Khalid bin Walid at once perceived their error, who made the best of this opportunity. He wheeled his squadron and launched a reinforced attack on the rear of the Muslims, causing a great havoc. This turned the scales against them and the Muslims began to flee before the Khalid's lancers, who certainly took a heavy toll of Muslim lives. M.H. Haykal writes in "The Life of Muhammad" (Karachi, 1989, p. 265) that, "Muslim morale plunged to the bottom, and Muslim soldiers fought sporadically and purposelessly. This chaos was responsible for their killing of Husayle bin Jabir Abu Hudhayfah by mistake, as everyone sought to save his own skin by taking flight except such men as Ali bin Abu Talib whom God guided and protected."
Muhammad was also embosomed with the enemies, until his front teeth were broken. Ali hurled himself into the fray, and shielded Muhammad and dashed the raiders. The Meccans, tired out by a long and gruelling day, began to retreat, and in their retreat vented their rage on the Muslims dead in the field mutilating the corpses. With a final taunt to the Muslims, Abu Sufian ordered withdrawal, and both the fighting men and the baggage train moved off. For a time it seemed that they might lay another ambush the town of Medina, but they left it alone and headed for Mecca. The Meccans lost twenty eight in the battle, while seventy men were killed among the Muslims. Among the slain, the body of Hamza was found mutilated, who had been laid low by a spear thrust which pierced him. The fiend Hinda, wife of Abu Sufian, had cut open his body, and took a piece of his liver and gnawed it to quench her thirst for the vengeance of her father, Atba who was killed by Hamza in Badr. Because of this, Muawiya, the son of Hinda was called the "son of the liver eater."
On his return to Medina, Muhammad directed a small body of the disciples to pursue the retreating Meccans, and to impress on them that the Muslims, though worsted in battle, were yet unbroken spirit. Abu Sufian, hearing of the pursuit, hastened back to Mecca. He however sent a message to Muhammad, saying that he would soon return to exterminate him and his people.
Shortly after the battle of Uhud, a famine broke out in Mecca and its environs. When Muhammad heard of their hardships, he immediately appealed the Muslims for help. Donation poured in and when a sizable amount was collected, he sent it to Mecca. This gracious gesture made little impression on his foes, who accepted the help but refused to soften their hearts or to relent in their opposition.
The Muslims were still beleaguered on all sides by their enemies, the Jews, the Bedouin tribes and the traitors from Medina. They kept nagging the Muslims with constant raids which were stoutly repelled and petty machinations which were effectively countered. The Jewish tribes had been expelled from Medina because of their inimical and treacherous behaviours, entrenched themselves in a place called Khaibar.